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Description
GA inhibited angiotensin-I converting enzyme (ACE), leading to reduced blood pressure in spontaneously hypertensive rats (SHR) comparable to captopril (Kang et al., 2015)

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However, in heart failure, pathological cardiac structure and functional reconstruction are often accompanied by significant reshaping in energy generation and transfer reshaping, manifested as a significant decrease in the metabolic efficiency of fatty acids and carbohydrates for energy but an increase in ketone oxidation (Lopaschuk and Ussher, 2016

Additionally, both the time to thrombosis and the area of adhesion significantly increased after exposure to TMAO in these aggregation experiments

10.1053/ajkd.2001.27408 22 HagbergH.MallardC.RoussetC

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