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In addition to contributing to its slow removal from the blood was a lack of phase I metabolism

doi: 10.1104/pp.010107

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(New York, N.Y.) 285 (5424), 100102

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In contrast, APT1 knockdown did not significantly alter VEGFR2 levels, although downregulation of VEGFR2 with VEGF-A and upregulation with PLGF treatment was observed, as has been reported in other systems 47