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Selenium, a chemical element, is indispensable for the optimal operation of numerous physiological processes within living organisms, including humans [58]

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This finding clarified that many GPx isoforms are selenium-dependent, leading to the recognition of GPx1 as the most efficient peroxide removal system in mammalian cell cytosol [3]

Following the loss of dopamine-producing neurons, there is a subsequent degeneration of other neuronal subtypes, giving rise to symptoms unresponsive to dopamine modulation