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It has been estimated to affect ~1% of the general population in the United States according to the Center for Disease Control and Prevention (CDC), and women are affected at a rate 3 times higher than men (42, 109)

to GEN positive control group (Somda et al

Koplin, A

While BVZ is well tolerated, suppression of VEGF activity often results in some common toxicities, such as hypertension, gastrointestinal perforation, thromboembolic events, cerebral haemorrhage, problems with wound healing, and proteinuria etc

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The delayed elevation of ALT compared to LDH can be explained by the fact that it is exclusively released by hepatocytes in the model, whereas LDH is expressed ubiquitously and the vascular toxicity that occurs contributes to LDH accumulation