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Shroff GS, Carter BW, Viswanathan C, Benveniste MF, Wu CC, Marom EM, Mawlawi OR, Truong MT

The system net charge was neutralized by adding Na + or Cl randomly placed in the box

Desideri G, Castaldo G, Lombardi A, Mussap M, Testa A, Pontremoli R, et al

Rat blood serum samples were pre- equilibrated at 37C and then (50g) of each drug solution was added to 90 of rat serum in 1 .5mL Eppendorf tube maintained at 37C

Thus, it is possible that PI3Ks have the following dual action on folate cycle regulation: on the one hand, by inhibiting GSK3A/B, reducing MTHFR phosphorylation, and, consequently, increasing its activity, and, on the other hand, by activating mTOR signaling for the transcription factors that regulate the gene expression of folate cycle enzymes

Both ferrous and ferric ions are involved in the conversion of PLOOHs to the free radicals PLO and PLOO, which trigger damaging peroxidation chain reactions[13, 43]