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NNMT methylates nicotinamide (a form of vitamin B3) using S-adenosylmethionine (SAM) as the methyl donor

Pediatric obesity is common, but safety and efficacy data for tirzepatide in children and adolescents are limited

Key Research Areas Lipolysis & fat-cell metabolism Studied in adipocyte models for stimulation of lipolytic activity and inhibition of lipogenesis

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We show that the inflammatory response elicited by elevated intracellular lipids in skeletal muscle is repressed in Cpt1b m/ mice, strongly supporting the hypothesis that mitochondrial processing of fatty acids is essential for the lipid-induction of inflammation in muscle