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while the noval approach include the detoxification using nanoparticals, plant extracts, pulse electric field (PEF), uning omics studies, etc

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Examples of drugs that can cause interactions with methotrexate are listed below

Overcoming these challenges requires spatiotemporally dynamic regulatory strategies: maintaining appropriate ammonia levels during early treatment to promote T cell function, while controlling toxicity in later stages through lysosomal pH modulators (e.g., C381) or urea cycle enzyme activators