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doi: 10.1111/bjh.12959

Two recent meta-analyses that pooled data from patients with end-stage renal disease found no benefit of B-vitamin supplementation on stroke outcomes (34, 35)

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Given the inconvenience of regular intramuscular injections and the evidence from several trials demonstrating the effectiveness of the oral route in normalizing vitamin B12 levels [57,73], we initially suggest a trial of oral replacement