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The rapid phosphoproteome quenching is extremely important for studies investigating the rapid phosphoproteome response to treatments occurring in seconds to minutes after stimulation
Clinicians and patients are cautioned that the procedure is indicated for frequency/urgency symptoms and is much less effective and potentially ineffective for pain
It also decreases motivation and the desire to make lifestyle changes that are beneficial for treating anxiety and depression
Conflict-of-interest statement: The authors state that they have no conflicts of interest
