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Silybin and silymarin have been shown to exhibit antimicrobial activity against gram-positive bacteria and increase the effect of resistant S.aureus to antibiotics (5,10)

Elevating NAD + has been demonstrated to exert unintended consequences, including off-target effects on sirtuins, PARPs, and CD38, which may result in immune dysregulation or altered DNA repair responses (Covarrubias et al

PLoS ONE 7 , e32754 (2012)