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Mechanism: Four Pathways, One Stack Each pathway maps to different receptors and partially distinct brain regions

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Kim EH, Surh YJ (2008) The role of 15-deoxy-12,14-prostaglandin J2, an endogenous ligand of peroxisome proliferator-activated receptor , in tumor angiogenesis

This excitotoxicity is not limited to cortical areas but also occurs in subcortical structures like the IC, where salicylate-induced neuronal hyperactivity and oxidative injury are closely linked to NMDA receptor-mediated mechanisms (Wang et al., 2023)

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J Clin Invest 58:180189