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Thus, in a randomized clinical trial conducted in selenium-sufficient GD patients treated with methimazole, no beneficial effect of Se on the short-term control of thyroid hyperfunction was observed ( Oxidative stress plays a significant role in the pathogenesis of GO and GD (the balance between oxidants and antioxidants is disturbed in favor of ROS), and an antioxidant approach is proposed for treatment ( 2 O 2 to induce OS, the antioxidants vitamin C, N-acetyl-L-cysteine, melatonin, retinol, -carotene and vitamin E were found to reduce the manifestations OS (proliferation of fibroblasts, the level of hyaluronic acid, the level of tumor necrosis factor- (TNF-), IFN- and IL1-, which provided the basis for the possible clinical use of these substances in patients with GO ( Treatment for GO, which is an extrathyroidal manifestation of GD, includes intravenous glucocorticoids and orbital radiation therapy and is generally offered to patients with moderate to severe GO

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IGF-I is a 70 amino-acid peptide, found in the circulation, 99% bound to transport proteins