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The administration of H 2 to mice, rats, and racehorses subjected to acute or chronic exercise stress was found to exert anti-fatigue effects (4649)

86 Some evidence suggests individuals with MTHFR polymorphisms may need higher doses of folic acid to experience therapeutic benefits and may respond better to supplementation with 5-methyltetrahydrofolate (5-MTHF), the active form of this B vitamin

Accumulating evidence indicates that flavonoids exert anti-inflammatory effects by regulating neutrophil function and inhibiting NETs formation through multiple signaling pathways

However, tumor-associated blood vessels are dysfunctional and leaky (93), and the continuous exposure of BECs to pro-angiogenic factors can lead to endothelial anergy, a state in which ECs stop responding to inflammatory signals (90)

doi: 10.1161/CIRCULATIONAHA.118.035889

Cells 11 , 2929 (2022)