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Semaphorin 3D (SEMA3D) increases lactate secretion via a KRAS mutation-dependent ADP-ribosylation factor 6 (ARF6) signaling pathway and induces pro-metastatic M2 polarization through the G protein-coupled receptor 132 (GPCR132) (209)

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PT AQP4+ modulated renin-angiotensin system (RAS) in the mice kidneys Another major change in PT in early DKD was a decrease in the number of PT AQP4+