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Protective and pathological immunity during central nervous system infections

In response to increased iron load or inflammatory stimuli, hepcidin expression is upregulated

This can explain why ifenprodil has been approved for clinical use in Japan and France, and a similar compound in the USA (107)

Cytochrome P450 family 1 subfamily a member 1 Cytochrome P450 (CYP) enzymes, specifically the CYP1A subfamily constitute a diverse group that plays pivotal roles in metabolizing both, internally generated (endobiotic) and foreign (xenobiotic) substances within the human body (Danielson, 2002)

The logic is that local administration creates higher peptide concentrations at the relevant tissue

doi: 10.1038/ni1582 330 VlasovaA