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(10) found that in mice fed with a methionine-choline-deficient diet, the expression of -SMA and GPR91 is enhanced, while metformin administration reduced overexpression in the liver, ameliorating steatohepatitis and liver fibrosis in mice
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doi: 10.5812/nms.10661 64 MathewsDMPeartJMSimRGJohnsonNPOSullivanSDerraikJGBet al

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Do not use the cream on your entire face at first, but try using a small amount behind your ear

Increased oxidative stress
