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Con la talidomida, un frmaco inmunomodulador popularmente conocido por sus propiedades teratognicas y que ha sido aprobado para el tratamiento del mieloma mltiple50,51, se han descrito incidencias variables en funcin de la duracin del tratamiento y la dosis total acumulada

To defend the deleterious effect of the stimulated chemotaxis, GER and SAP adaptive response induces the expression of anti-oxidant genes and stimulates the production of anti-oxidant enzymes that quench the free radicals and suppress the deleterious effects of the free radicals, thus inhibiting cell or tissue lysis
doi: 10.1002/cld.929 [PubMed] 33409766 Redant S, Empain A, Mugisha A, Kamgang P, Attou R, Honor PM, De Bels D
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Arch Phys Med Rehabil 1996;77:824-6

Extracellular osmolarity of medullary cells may become more than four-fold that of isotonicity [50]
