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Mol Metab 5: 480490, 2016

Williams, MA

While synovitis serves as a principal cause of pain in RA, emerging evidence suggests that numerous patients persist in reporting pain despite the apparent control of inflammation (Simon et al

Similarly, TMAO increased the mRNA expression of the stress-induced heat shock proteins HSP60 and GRP78, a hallmark of endoplasmic reticulum stress induction, which was related to an increased risk of AS (Mohammadi et al., 2015)

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While there is no evidence of common structural or functional brain alterations in PAIS, probably due to its heterogeneous origin and lack of conceptualization, ME/CFS has been extensively studied with MRI (magnetic resonance imaging), as recently reviewed by Nelson et al