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Thiamines antioxidant function, specifically its ROS scavenging, leads to a much greater reduction in hydroxyl radicals (HO) compared to hydroperoxyl radicals (HOO) [8]

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This gives rise to the formation of a stable amide bond

Some have FDA approval for very specific conditions (e.g., tesamorelin for HIV-related lipodystrophy), but using them outside of that is considered off-label

Curr Ther Res Clin Exp