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Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

Moreover, some gut microbiota metabolites play a harmful role in the occurrence and development of CVDs

Apart from Nlrp3 inflammasome, mitogen-activated protein kinases (MAPK) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) are involved in the pathogenesis of chronic inflammation (47)

These findings underscore the critical role of anionic composition in Mg supplementation for optimizing region-specific therapeutic outcomes

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For HCC, several therapies or drugs have been tried in the clinic, but no breakthroughs have been achieved, and even some approved drugs later failed to inhibit tumor growth due to the emergence of drug resistance mechanisms