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In some embodiments, local otic delivery of the auris formulations or compositions described herein allows for controlled release of active agents to auris structures and overcomes the drawbacks associated with systemic administration (e.g., low bioavailability of the drug in the endolymph or perilymph, variability in concentration of the drug in the external, middle and/or internal ear)

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83.53 0.7815, Figure 1A, Mean SEM, n = 6), and the brain water contents of the vitamin B12-treated TBI groups were reduced to differing degrees relative to the TBI group (86.11 1.070 in 0.5 mg/kg vitamin B12 dose group and 85.31 0.7846 in 1.5 mg/kg vitamin B12 dose group vs