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Iwanaga et al also implicated the NFB consensus element, but not AP-1 or ARE, in mediating the effect of ionizing radiation on GCLC expression in a human glioblastoma cell line (Iwanaga et al., 1998)

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3T3-L1 preadipocytes respond to IGF-1 LR3 through both IGF-1R and insulin receptor hybrid receptors, making them relevant for adipogenesis and metabolic signaling studies

The role of SAM consists in positive allosteric feedback activation: SAM production in transmethylation path enhances the whole process