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10.1016/j.biopha.2005.06.014

IADL, Instrumental Activities of Daily Living

Cellular defenses are activated in response to insults to oxidized DNA and include four major repair mechanisms: 1 ) nucleotide excision repair (NER) and 2 ) base excision repair (BER), both of which excise bulky helix-distorting DNA lesions

Gene expression on BDNF and SK-3 was quantified using real-time PCR, revealing that VPA reduced the expression BDNF, which plays a crucial role in synaptic plasticity and neuronal survival, and increased GSK-3, which is involved in neurodevelopment and neuroinflammation whereas crocin dose-dependently normalized both markers (Hosseini et al., 2025)