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In controlled human research, higher-dose resistant starch over weeks has been linked to modest weight loss with a disproportionately large drop in abdominal visceral fat stores on imaging, alongside improved insulin sensitivity, even without prescribing calorie restriction

Notably, certain pathologies such as renal dysfunction may also present with increased levels of MMA

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Myelin Synthesis : Vitamin B12 is a cofactor for the enzyme methionine synthase, which is involved in the conversion of homocysteine to methionine

Indeed, it is required for efficient promoter recognition by mitochondrial RNA polymerase and binds and induces significant conformational changes in mtDNA
