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Recently, a new DON prodrug JHU395, has been developed to treat medulloblastoma (Pham et al., 2021)

A significant reduction in exacerbation frequency was found in the preliminary results of a trial with 89 patients which compared the use of azithromycin with a placebo40 as well as in another study yet to be published with 117 patients using erythromycin.41 Accordingly, the largest study to date, which has recently been published,42 demonstrated that a 6 months azithromycin treatment significantly decreased the rate of exacerbations requiring antibiotic therapy, which was sustained for 6 months after completion of treatment, and increased the time to the first exacerbation requiring antibiotics

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It is interesting to speculate whether the ability of digoxin to inhibit both osteoclast differentiation and hypoxic bone resorption by mature osteoclasts is due to its ability to inhibit both isoforms of HIF

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The mechanism of ferroptosis is complex and varied but it is essentially an imbalance between oxidation and antioxidant systems, resulting in cellular lipid peroxidation (62)