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2.1 Cisplatin-induced DNA damage and apoptosis Once cisplatin enters the cell it can be hydrolyzed to form toxic aqua-cisplatin complexes and form intra-and interstrand crosslinks with DNA (Johnstone et al., 2016), the formation of such DNA adducts induces structural distortions of the DNA helix, which in turn leads to DNA damage, which activates multiple signaling pathways, one of which is the activation of the ATM-Chk2-p53 pathway (Benkafadar et al., 2017)

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Some research also suggests that vitamin C may play a role in toxin removal

Pharmacognosy 17 edn, 149 (Bahive Tinal, 1985)

In the cortex, only concentrations of glutamate correlated with memory performance ( r = 0.34, p = 0.035, Figure 2C)