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In elderly persons, for example, serum total homocysteine concentration is often elevated in those whose folate status is normal but who have a clinical response to B12 treatment (Stabler et al., 1996)

That being said, B12 injections may be administered in office 1 to 2 times per week as well as at home
The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications

If anything becomes worse rather than better after 48 to 72 hours, call the clinician who gave you the shot
