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Abstract Migraine is a chronic, recurrent neurovascular disorder characterized by episodes closely associated with neurovascular hypersensitivity

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Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but Not Sema III

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Neuropathic pain is often chronic, and neuropathic symptoms (i.e., component) are frequently reported and aggravate painful, non-primary neurological conditions in spite of no demonstrable neuronal injury (Scholz et al., 2019)