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Meldonium (Shenzhen Calson Bio-Tech Co., Ltd., China) concentration in water was adjusted weekly to achieve daily animals consumption of around 300 mg/kg b.m

Chronic exposure to sertraline was shown to down-regulate expression of drug- and arachidonic acid-metabolizing enzymes in hepatic tissue, indicating that patients using this drug may be at risk of hepatotoxicity with reduced capacity to metabolize drugs and fatty acids (Almansour et al

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