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To generate consensus sequence contigs, Pacific Bioscience reads were mapped with minimap2 (v.2.16) 100 and to the obtained contig assembly in two rounds using the wtdbg2 polishing module

Yet, these therapies fail in many patients for a variety of reasons, including CD8 + T cell exhaustion and immunosuppression by the TME due to low oxygen and competition for nutrients between tumor cells and immune cells (126)

This process continues until a hair follicle is finished with its growth phase

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While certain risk factors like age, genetics, and