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In addition to severe pain, the skin has been characterized as having a woody induration and cobblestoned

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doi: 10.1038/s41586-025-09460-7 118 GongKHuangYZhengYZhuYHaoWShiK

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Results: Compared with the vehicle control group, we found that mice injected with Diprotin A TFA exhibited reduced cerebral infarction volume, increased vascular area and length around the brain injury, increased pericyte and basement membrane coverage, upregulated expression of BBB tight junction proteins, and improved their BBB permeability, whereas the group injected with both drug and inhibitor exhibited significantly aggravated vascular injury and BBB permeability

Additionally, the expression of ACSL1 is significantly increased in the exfoliated urine cells and urine supernatant of diabetic nephropathy patients and is closely related to renal function 61