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Some aspects of metformins mechanism of action are still not fully understood [57]
doi: 10.1016/j.tips.2017.07.001 [DOI] [PubMed] [Google Scholar] 37

2 If the sleep-wake cycle is compromised, cortisol levels fluctuate, which could result in an increased risk of high blood pressure

10.1016/j.lfs.2023.121915 [DOI] [PubMed] [Google Scholar] Pickart L

Summary A swollen, inflamed, glossy-looking tongue is a sign of B6 deficiency
