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doi: 10.1016/j.plaphy.2005.01.002 6 BadejoA

2a and Supplementary Table 1) sequences representing canonical, well-characterized biological motifs (AP-1, CTCF, E-box, NF-Y, TATA, TEAD, the human ssDNA telomere repeat, and the c-Myc promoter Pu27 G4-quadruplex forming ssDNA sequence [mycG4] 25 )

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In one such study, lung and colonic organoid models showed SARS-CoV-2 infection was reduced when various SARS-CoV-2 entry inhibitors were applied [22]

Interestingly, recent studies have indicated that hypoxia can activate nitric oxide synthase and nicotinamide adenine dinucleotide phosphate oxidase, enzymes responsible for generating ROS, which are implicated in oxygen-induced retinopathy (Wang et al., 2013

Recently, we have shown that small biomolecular drug conjugate between 5-FU and bilirubin produced very high ROS generation in highly metastatic Daltons lymphoma (DL) cells as well as in doxorubicin resistant variant of DL cells [86]
