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Oxidative stress induced by iron overload may also contribute to the manifestation of macrovascular complications of diabetes, including atherosclerosis and cardiovascular diseases (266)

Melanin is a pigment found in the skin responsible for the darkening of skin tone as it consists of blackish-brown eumelanin and reddish-yellowish pheomelanin

1E) annotations revealed that the pathogenesis of Parkinson's disease is closely related to metabolic dysregulation, abnormal protein processing, and neuroinflammation

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Hypoxia induces the overexpression of Hilpda, which leads to triglyceride overload and FAO defects by downregulating adipose triglyceride lipase (ATGL), triggering mitochondrial dysfunction and upregulating profibrotic factors (TGF-1, -SMA, type I collagen) while reducing the expression of cyclin-dependent kinase 1 (CDK1) and increasing the CyclinB1/D1 ratio, collectively promoting renal tubular fibrosis [85]
