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The metabolic switch from mitochondrial respiration to aerobic glycolysis provides flexibility to sustain cellular energy

While AKR1B10 expression was significantly higher in HCC tumor tissues relative to normal tissues, AKR1B1 expression was not remarkably different between tumor and normal tissues

In particular, the glucose transporters GLUT1 and GLUT3 are more highly expressed in breast cancers, with lower differentiation [50]

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