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10.1038/ng746 Nat

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[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Mancias J.D., Pontano Vaites L., Nissim S., Biancur D.E., Kim A.J., Wang X., Liu Y., Goessling W., Kimmelman A.C., Harper J.W

This allowed us to observe a higher mitochondrial mass and membrane potential in aged Mda5 -/- HSCs, a characteristic of young HSCs 47,48,49 , albeit in studies utilizing verapamil (Fig

357 The in vitro culture of telomere-binding protein protection of telomeres 1 (Pot1) in HSCs has been demonstrated to maintain self-renewal capacity and regulate the activity of HSCs in elderly individuals, which has significant implications for the ex vivo cultivation of human HSCs