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leu2 0 / leu2 0

Yang, L., Zheng, L., Chng, W

Key numbers Oxidative only: G6P Ru5P + 2 NADPH + CO Full cycle (6 G6P in): 6 G6P + 12 NADP 5 G6P + 6 CO + 12 NADPH (net 1 G6P oxidized, 12 NADPH made) Thus PPP is the cells flexible supplier of reducing power and ribose, letting any tissue match antioxidant and biosynthetic needs without leaving central carbon metabolism

depleted sod-C (sodC) mutant and sodC mutant with attenuated sod-B gene expression (sodB sodC) exhibited attenuated intracellular survival in IFN--activated macrophages compared to the wild-type LVS

Under normal physiological conditions, oxidative stress plays an active role in adaptive stress responses (e.g., NAFLD detoxification, molecular damage repair, anti-inflammation, and tissue regeneration), such as by promoting cell autophagy and mitochondrial autophagy, which can effectively deal with acute exposure to cellular stressors

Some reported adverse events included nausea and vomiting, urinary retention, tachycardia, constipation, and blurred vision