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The impairment in the Krebs Cycle may induce inflammatory pathways through the promotion of mitochondrial ROS production (Fig

doi: 10.1152/physiolgenomics.00207.2007

Studies comparing 8-OHdG levels in the urine of AD patients and healthy controls have demonstrated positive correlations between 8-OHdG levels and dermatitis scores, indicating disease severity

Eukaryotic translation initiation factor 5A (eIF5A) is a highly conserved protein that contributes to the expression of various mitochondrial proteins, and some of these proteins are involved in the TCA cycle and OXPHOS

doi: 10.1016/j.bbrc.2009.06.137

Thus, while AHR represents a promising target for immune modulation, orally bioavailable AHR agonists with improved safety profiles are urgently needed