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Description
Its main active ingredient, total dajizin triterpenes, reduces the expression of ACSL4 in the rat model of RA, increases the expression of glutathione and GPX4, and upregulates Kelch-like ECH-associated protein 1 and HO-1 in the Nrf2/HO-1/GPX4 pathway, indicating that total dajizin triterpenes can inhibit cell aberrant ferroptosis by suppressing lipid peroxidation and thus exert therapeutic anti-RA effects [168]

Their ability to target key signaling pathways involved in CRC progression, such as the Wnt/-catenin, PI3K/Akt, nuclear factor kappa B (NF-B) pathways, and transforming growth factor-beta (TGF-), positions them as promising agents for chemoprevention and adjunctive therapy (3, 4)

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Shock 12, 229239
S., You H., Gao T., Cooper T

Huber N, Guimaraes S, Schrader M, Suter U, Niemann A
