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Am J Gastroenterol 92:5S-11S Thoreson R, Cullen JJ (2007) Pathophysiology of inflammatory bowel disease: an overview

Characterization and qualification of cell substrates and other biological materials used in the production of viral vaccines for infectious disease indications

For instance, building upon the established role of GPX4 in suppressing ferroptosis in alveolar cells, the demonstrated therapeutic potential of mesenchymal stem cell-derived exosomes, the feasibility of CD44-mediated macrophage targeting, and the precedent for pulmonary nucleic acid delivery, the engineering of inhaled exosomes to deliver GPX4 mRNA specifically to alveolar macrophages represents a promising frontier (175, 178)

However, regardless of the specifics of the study design, participants safety should always be an utmost priority when conducting an FIH trial