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Despite the concerns and limitations noted, there is no doubt that NQO1 has evoked great interest encompassing the areas of tumor biology, drug discovery, chemistry, and cancer imaging and has emerged as a tumor-selective drug target

US20230242479A1 - Alkylamine-substituted perthiocarbamates as dual precursors to hydropersulfide and carbonyl sulfide - Google Patents Alkylamine-substituted perthiocarbamates as dual precursors to hydropersulfide and carbonyl sulfide Download PDF Info Publication number US20230242479A1 US20230242479A1 US18/159,447 US202318159447A US2023242479A1 US 20230242479 A1 US20230242479 A1 US 20230242479A1 US 202318159447 A US202318159447 A US 202318159447A US 2023242479 A1 US2023242479 A1 US 2023242479A1 Authority US United States Prior art keywords group compound alkyl ischemia rssh Prior art date Legal status (The legal status is an assumption and is not a legal conclusion

Exposure to paraquat can induce pulmonary toxicity which has been demonstrated in previous studies that showed retention of paraquat occurs higher in the lung than in other organs (Sharp et al., 1972)

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In this cycle, GSH is released from the cell by carrier mediated transporter(s) and the ecto-enzyme GGT then transfers the -glutamyl moiety of GSH to an amino acid (the best acceptor being cystine), forming -glutamyl amino acid and cysteinylglycine