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The combination of elevated proinflammatory and decreased anti-inflammatory cytokines suggest that the destructive impact of inflammation could be severe in aging
2.2.3 Duration of disease, motor symptoms, non-motor symptoms, and associated microbiota The composition of gut microbiota might vary whether PD has an early or late onset

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[DOI] [PMC free article] [PubMed] [Google Scholar] 742

McCarthy, for example, has provided a plausible explanation for the idea that inhibition of prostaglandin synthesis (by acetaminophen, for example) would have a much different effect on the male brain than on the female brain

Recent research has suggested that the microbiome-derived metabolite trimethylamine N-oxide (TMAO) may be a driver of antitumour immunity [237] and that microbiota-derived 3-IAA can influence chemotherapy efficacy [238]
