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N-acetylcysteine is a prodrug for cysteine which is the rate-limiting substrate in glutathione synthesis and is typically found as a dietary supplement

NF-B signaling, NLRP3 inflammasome signaling, JAK-STAT signaling, Toll-like receptor signaling, and cGAS-STING signaling are major signaling pathways that mediate inflammation in inflammatory cells including immune cells and injured renal resident cells

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