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The homocysteine-inducible, endoplasmic reticulum (ER) stress-inducible, ubiquitin-like domain member 2 (HERPUD1) in cultured HELA cells facilitate cytoprotective effects against oxidative stress by suppressing the inositol 1,4,5-triphosphate receptor and reducing the transfer of calcium ions from the endoplasmic reticulum to mitochondria [41]

One common indicator is persistent fatigue or weakness

Gut protection: Strong data in rodents demonstrates protection against gut lining injury ( inflammation, epithelial repair) relevant for athletes with high training stress or NSAID exposure

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10.1159/000346968 [DOI] [PubMed] [Google Scholar] EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies) (2015)