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4.3 Blood pressure effects A 2024 umbrella meta-analysis (n = 2,008) of randomized controlled trials found that magnesium supplementation lowers blood pressure, although effects were modest and varied by baseline status, dose, and treatment duration ( 4.4 Endohelial function Preliminary mechanistic studies suggest magnesium may improve surrogate vascular endpoints

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This cellular HTS is based on protein-fragment complementation assays (PCAs), in which the protein of interest is fused to fragments of a reporter protein whose activity is recovered upon binding

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doi: 10.1186/s13287-019-1181-5 14 KangariPTalaei-KhozaniTRazeghian-JahromiIRazmkhahM

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Journal of Preventive Medicine and Public Health, 45 (6), 353363

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This is highlighted by endomyocardial biopsy specimens revealing inflammatory macrophage infiltrates (58) and apoptotic myocytes on caspase 3 positive cytoplasmic staining (58)

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