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In the context of cancer, NRF2 has traditionally been considered a tumor suppressor because its cytoprotective functions are considered the main cellular defense mechanism against exogenous and endogenous insults, including xenobiotics and oxidative stress

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To keep GSH in a reduced state, the cytosol and the mitochondrial matrix harbour the NADPHdependent enzyme glutathione reductase (encoded by GLR1 in Saccharomyces cerevisiae )

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(1985) Iron accumulation during development and ageing of Drosophila

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