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Nature 2014, 516, 231233

Commonly, pronounced edema and congestion in the brain tissue were presented in controls

It is important to mention here that polyphenols cannot cross the blood-brain barrier and may have low bioavailability in the brain, but the intestinal lumen contains them in abundance, and hence, have the ability to modulate the microbiota, which is of utmost importance in the pathogenesis of ASD [197]

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Acknowledgements The authors are supported by National Institute of Diabetes and Digestive and Kidney Disease grants R01DK61931 and R01DK68271 (J.R.T.), U.S

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