mechanism for the several activities of the glutathione s-transferases S-transferase: A keystone in Parkinson's disease pathogenesis and therapy Alterations in the glutathione and

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However, in cocaine addiction, most of the research focusing on mechanisms of action has implicated the modulation of the cystineglutamate antiporter by NAC as the most likely cause of benefit.26,82,83 Whereas there are similarities across these disorders with alterations to oxidative biology and neurotransmission, and changes in glutamate-dependent long-term potentiation and neuronal plasticity,84 perhaps the heterogeneity of the underlying pathologies, especially in brain regions implicated, may lead to the revelation of different actions of NAC depending on the disorder

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doi: 10.21873/anticanres.11574 82 LiaoLGeMZhanQHuangRJiXLiangXet al

Biomolecules 15 (7), 911 (2025)