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This receptor modulation triggers a cascade of intracellular signaling events that ultimately result in the activation of hormone-sensitive lipase, the enzyme responsible for breaking down stored triglycerides into free fatty acids and glycerol
GLP-1 agonists work primarily through appetite suppression and slower gastric emptying

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Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts

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The peptide demonstrates regional selectivity in its fat-reducing effects, showing particular efficacy in reducing visceral adipose tissue (deep abdominal fat) and subcutaneous fat deposits
