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However, the magnitude and extent of changes in glutamatergic metabolites in schizophrenia are not clear

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These catechols are substantially more polar and can be directly excreted, or oxidized by dehydrogenases to yield reactive quinones (which are substrates for Phase II metabolism)

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Oral Formulation Absorption Challenges Oral Slupp332 faces a more complex journey to reach therapeutic concentrations: Stomach acid exposure : The acidic environment (pH 1.5-3.5) can denature peptide structures, breaking bonds and rendering the compound inactive
